CREATINE-HCL STABILITY NARRATIVE
Based on Patented “Creatine Hydrochloride”
Donald W. Miller, Ph.D.
Department of Pharmacology and Therapeutics
University of Manitoba
With regard to latent product storage, standard shelf-life according to the FDA is considered to be the time it takes for 10 percent of the starting material to degrade in a given sample. Creatine monohydrate typically exhibits a shelf-life of about one week when stored in aqueous solution at room temperature. In contrast, the creatine HCl possesses a shelf-life of at least 45 days or greater in aqueous solution. In one study, the shelf-life of the creatine HCl in aqueous solution showed to be at least 60 – 75 days. In another study, the creatine HCl possessed a shelf-life of about 90 days or greater in aqueous solution. Stability may be longer but longer studies have not yet been performed.
Higher temperatures accelerate degradation of all forms of creatine, including the creatine HCl. However, when exposed to higher temperatures, creatine monohydrate still degrades at a much higher rate than creatine HCl. In one study, the shelf life of creatine HCl in aqueous solution at a temperature ranging from about 10 to 20 degrees (°C) higher than room temperature is at least about 14 – 30 days. In another test, the shelf life of the creatine HCl at 50°C is at least about 1 – 5 days. All of these results are much improved vs. creatine monohydrate.
Figure 1: Illustration of chart or graph to show some of the info in a visual.